Menorrhagia - Women Rare Bleeding Disorders

Healthcare providers consider potential causes of menorrhagia, including local or systemic disorders.

table 1

local uterine causes
	endometrial hiperplasia
	endometrial carcinoma
	endometrial polyps and fibroids
	polycystic ovary disease
	uterine infection
systemic causes
	endocrine disorders (hypothyroidism, diabetes mellitus, ecc)
	liver disease
	chronic cardiac or renal disease
	obesity
	bleeding disorders

However a specific cause of this problem is identified in only 50% of affected women.

Bleeding disorders can evade diagnosis until menarche, when heavy menstrual bleeding presents as an unrelated disorder.

Up to 20% of women with menorrhagia have an underlying bleeding disorder, the most frequent being von Willebrand disease (VWD) [4] and platelet disorders [1]. Among other bleeding disorders haemophilia carriers and deficiencies of fibrinogen, factor II, V, V+VIII, VII, X, XI and XIII are included.